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Posted at December 31, 1969, 6:00 pm: Well Sherlock, as yet I don't think we've seen any research on how 3,5-T2 or 3,3 T2 affects TSH in humans. In fact, it's not known to the best of my knowledge how 3,5-T2 (3,3-T2) operates to suppress TSH in rodents or humans. A couple of models have been proposed. One is that at sufficiently high concentrations T2 may bind to the pituitary T3 receptor and act in a negative feedback manner to suppress TSH. Another proposal is that T2 increases levels of pituitary 5'deiodinase, the enzyme that converts T4 to T3, and the resulting T3 lowers TSH. I have read in several papers and texts that rats have very little TBG ( Thyroxine Binding Globulin) compared to humans, so the thyroid hormones have much shorter half lives in rats than in humans. This suggests the rapid elimination of T3 and its metabolite T2 might lead to less buildup of T2 in the rat pituitary compared to the human pituitary, leading to even greater suppression of TSH in humans compared to the data reported for rats. Some food for thought anyway. Original of the message was taken from http://forum.bodybuilding.com/ Previous Post: You need to learn a lot more about thyroid hormones and their molecula... Next Post: Here is another research paper to consider: Metabolic Effects of Th... |