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Posted at November 27, 2013, 10:22 am: I am sure deserusan has posted some nice information on the subject in his logs, but I wanted to create a thread specific to the science in support of adding a KIC to Leucine, such as Muscle Tech's Leukic Product. Many are asking; hopefully this should serve as a starting point. What are Free Form Amino Acids: http://www.getbig.com/articles/protein.htm What is Leucine http://en.wikipedia.org/wiki/Leucine What is Alpha-Ketoisocaproate: http://www.nutriline.org/alpha-ketoisocaproate.htm What is phosphorylation: http://en.wikipedia.org/wiki/Phosphorylation Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate. Yoshizawa F, Sekizawa H, Hirayama S, Yamazaki Y, Nagasawa T, Sugahara K. Department of Animal Science, Utsunomiya University, 350 Mine-machi, Utsunomiya, Tochigi 321-8505, Japan. fumiaki@cc.utsunomiya-u.ac.jp The indispensable branched-chain amino acid leucine acts as a key regulator of mRNA translation by modulating the phosphorylation of proteins that represent important control points in translation initiation, including the translational repressor, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase (S6K1). In the current study, we compared the effects of L- and D-enantiomers of leucine on the phosphorylation of 4E-BP1 and S6K1. We also assessed whether leucine itself or its metabolite, alpha-ketoisocaproate (alpha-KIC), mediates the effects of leucine. Food-deprived (18 h) rats were orally administered 135 mg/100 g body weight L-leucine, D-leucine or alpha-KIC and were sacrificed after 1 h. L-Leucine administration had an obvious stimulatory effect on the phosphorylation of 4E-BP1 and S6K1 in both skeletal muscle and liver while D-leucine was much less effective, indicating that the effect of leucine is stereospecific. Oral administration of alpha-KIC mimicked the stimulatory effect of L-leucine in skeletal muscle. In contrast to skeletal muscle, provision of alpha-KIC was significantly less effective than L-leucine in the liver. The results showing that the efficacy of L-leucine and alpha-KIC in stimulating phosphorylation of S6K1 and 4E-BP1 is equivalent in skeletal muscle, may be explained by the conversion of alpha-KIC to L-leucine. Best wishes, and Happy Hypertrophy™. Original of the message was taken from http://forum.bodybuilding.com/ Replies:good thread Hal.this one found that KIC (actually ketoisocaproic acid) + BCAA's had no... Thanks Halleluyah: excerpted: "Most experts believe that KIC... Nice info! Just started my Leukic/Gakic/Anator stack three days ago... **waiting for Anssi to get in this thread and start posting** **Mixing MyoZene and H+Blocker containing pre-exercise drink** Nice find Hal more on the HMB Supplementation With ß-Hydroxy-ß-Methylbutyrate (HM... Do you people think this will make a giant difference in your yearly r... Bumping for input to the above ^^^. Haha! Good read. I can see why this study would be mentioned but it really doesn't have... no, you are correct. Excellent post des. well, is it correct that KIC is a metabolite of L-leucine? If so, to ... This is a great thread and I'll be posting in it more once I'm back fr... Looking forward to reading more input from you on this subject. Can't wait for the log. what would you guys say is optimal dose of KIC when combined with leuc... Under a gram of KIC per serving, I believe. Bump I did a bottle of Leukic with HMB with nice results that made a believ... Other Topics of Body Building:Eating when hungryBATMAN BEGINS Sequel Title CONFIRMED! my arm while lifting Eating Disorder Support Group Darren's Profile Larry Allen's big bench The Official "Over 50" Thread The Greatest Biceps Belong to Larry Scott. Am I doing too much cardio? Best support wear. would it be ok to have military press as a max effort lift for a few weeks with WSB What one excercise is best for shoulder mass? Gyno BodyShaping Compression Tank Tops What is the best way to find my 1RM? how much protein in egg whites? Helpfull routine Upper pecs old bloke 5x5 ? Antidote’s long strange trip to fat loss journal. Push Jerk vs Split Jerk, BTN vs from the rack Avodart alcohol want to know the secret? Quick Ab Shot Does anybody use weighted vests/belts for training? mass gains 4 Months of Working Out |