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Posted at July 29, 2013, 6:43 pm: http://www.precisionnutrition.com/me...ead.php?t=2218 Here's a mail I recently received from some friends (PhDs) in the Ex Sci/Nut Biochem community. It discusses the potential dangers and (flawed marketing picture) associated with the use of Creatine Ethly Ester: 1) CEE is a true covalently bonded ester and is absorbed into blood and tissues as the intact molecule. This is the picture that the manufacturers would have us believe and is the basis for why they claim CEE is superior to creatine monohydrate. However, inside cells CEE will be unreactive with creatine kinase and may be a potential competitive or non-competitive inhibitor to the enzyme. This would make it toxic to brain, heart, testes, muscle and all other CK containing tissues. People by now should be dying, but clearly are not and this means 2) and 3) are the more likely. Nonethess, CEE should be treated as a potentially toxic phrarmaceutical and in the US should be treated as a drug, which requires multi species studies to estimate LD50's and potential sites of tissue damage etc. However, recently I have been told that CEE did get new dietary ingredient status (scary). 2) CEE is hydrolysed to creatine on absorption from the gut. In this case CEE offers no advantage over creatine monohydrate which has a bioavilability of 100%. Indeed if hydrolysis of CEE is less than 100% then it will be inferior to the monohydate. But in the case of hydrolysis there are no circumstances in which it could be better than the monohydrate in increasing tissue creatine levels. Obviously CEE manufacturers would prefer 1) except that they then shoot themselves in the foot over the issue of potential toxicity. 3) CEE is not a true covalently bonded ester. The whole of this is a scam with the compound ionising in solution to free creatine, as does the monohydrate and all salts of creatine. In this case CEE would again represent no advantage over creatine monohydrate, except to the seller who can double the price. The failure of the US sports nutrition community (industry and the universities) to call for closer examination of CEE seriously questions its credibility in the eyes of many scientist in this country and the world. A simple water solvation test would answer 3), i.e. whether or not it was a covalent or ionisable derivative of creatine. The work time would be about one hour. Investigation of whether CEE is a competitive or non-competitive inhibitor of creatine kinase would take 2-3 hours. If either of these occured then clearly CEE must be investigated in at least two species to investigate lethality and potential organ damage. If on the other hand CEE is ionisable then I see no reason why a bioavailability study should not be undertaken comparing this, on a molar/molar basis, with creatine monohydrate. My guess is that plasma AUC would be identical. Again a very simple study. None of this is rocket science but could spare a few lives, if the manufacturers claims on the absorption of CEE are to believed. __________________ John M. Berardi, PhD, CSCS President, Science Link, Inc. Founder, Precision Nutrition Author, Scrawny to Brawny Original of the message was taken from http://forum.bodybuilding.com/ Replies:Very interesting, but considering it's popularity and overwhelmingly p...piitb. i never liked CEE myself, that's why I'm taking regular monohydrate no... im not john berardi I think its better off posted in the supplement science section. empty post I don't get it. no studies done on CEE. Thanks Layne. the way the dietary supplement act works is the FDA has to prove somet... Thanks for the info. word, my CEE is gone. There is nothing to worry about untill the worried guy really gets his... Kre-alkalyn is also a possiblity (for use) but i'll stick with my ... All I know is all my diets have been structured By Dr. kre-alkyln is BS why is that? with all the questions about the safety of CEE, I had ... I will not state whether I agree or not for political reasons, all I c... Just go with Monohydrate. http://www. So I think I'm going to stop taking cell mass and start up some Creafo... bloating is due to cell volumization. Other Topics of Body Building:How does leg positioning affect squatsThe Vegetarian Cut Diet hey bob , bout ur diet when u were getting ready 6'4" 195lbs. New MD Cover! Guess who? Rippetoe's program? NO side triceps in the Pro Division? noooo gf got worst haircut ever If i'm cutting and not losing over 2lbs/wk... 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